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KMID : 0191120100250050781
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Journal of Korean Medical Science
2010 Volume.25 No. 5 p.781 ~ p.784
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Hematopoietic Stem Cell Transplantation after Posttransplant Lymphoproliferative Disorder
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Kim Min-Joo
Kim In-ho
Bae Hyun-Mi
Suh Kyung-Suk
Park Nam-Jun
Yoon Sung-Soo
Park Seon-Yang
Kim Byoung-Kook
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Abstract
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A 16-yr-old girl received liver transplantation for fulminant hepatitis. Aplastic anemia developed, and she received hematopoietic stem cell transplantation (HSCT). Eleven months after liver transplantation, abdominal lymph node enlargement and colon ulcers were observed, and colon biopsy showed posttransplant lymphoproliferative disorder (PTLD). Immunosuppression reduction was attempted, but it produced no therapeutic effect. Fourteen months after liver transplantation, she received a second HSCT due to engraftment failure, and PTLD resolved completely. The second HSCT can serve as cellular therapy for PTLD.
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KEYWORD
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Posttransplant Lymphoproliferative Disorder, Hematopoietic Stem Cell Transplantation, Liver Transplantation
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